Structural genomics boost

Structural genomics

theory, based on the shape and location of coral formations, on coral’s inability to grow at depths greater than 30 fathoms, and most of all on a scenario for which he had no evidence: that each reef or atoll represents the outer limit of an island that has slowly subsided into the ocean. Read this chapter, if only to be struck by its masterly fusion of acute observation and trenchant imaginati...

Magnetic boost for structural studies

Researchers will soon be jostling for access to a new generation of NMR spectrometers allowing analysis of ever larger proteins, reports Michael Gross A shiny UFO has landed a few miles from Oxford, and rolled out a spiral staircase. That's at least what you might be forgiven for thinking when you see the latest product of Oxford Instruments: an NMR magnet muscling up to 21.1 tesla, correspondi...

Bioinformatics in structural genomics.

Expectations from structural genomics.

Structural genomics projects aim to provide an experimental structure or a good model for every protein in all completed genomes. Most of the experimental work for these projects will be directed toward proteins whose fold cannot be readily recognized by simple sequence comparison with proteins of known structure. Based on the history of proteins classified in the SCOP structure database, we ex...

Advances in structural genomics.

New computational techniques have allowed protein folds to be assigned to all or parts of between a quarter (Caenorhabditis elegans) and a half (Mycoplasma genitalium) of the individual protein sequences in different genomes. These assignments give a new perspective on domain structures, gene duplications, protein families and protein folds in genome sequences.